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Author Correction: Transposable elements drive widespread expression of oncogenes in human cancers

Nat. Genet.. 2019-05; 
JangHyo Sik,ShahNakul M,DuAlan Y,DaileyZea Z,PehrssonErica C,GodoyPaula M,ZhangDavid,LiDaofeng,XingXiaoyun,KimSungsu,O'DonnellDavid,GordonJeffrey I,Wang
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摘要

Transposable elements (TEs) are an abundant and rich genetic resource of regulatory sequences1-3. Cryptic regulatory elements within TEs can be epigenetically reactivated in cancer to influence oncogenesis in a process termed onco-exaptation4. However, the prevalence and impact of TE onco-exaptation events across cancer types are poorly characterized. Here, we analyzed 7,769 tumors and 625 normal datasets from 15 cancer types, identifying 129 TE cryptic promoter-activation events involving 106 oncogenes across 3,864 tumors. Furthermore, we interrogated the AluJb-LIN28B candidate: the genetic deletion of the TE eliminated oncogene expression, while dynamic DNA methylation modulated promoter activity, illustratin... More

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